Cyclobenzaprine Uses, Dosage & Side Effects

Cyclobenzaprine Uses, Dosage & Side Effects

It is usually prescribed to treat skeletal muscle conditions, strains, or other muscle injuries. The medicine may also be prescribed to treat back or neck pain, usually for only two to three weeks. Dantrolene (Dantrium) is a skeletal muscle relaxer used to treat muscle spasms caused by spinal cord injury, stroke, cerebral palsy, or MS. It works by acting directly on the skeletal muscle to relax the muscle spasm.

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When alcohol and cyclobenzaprine have been abused together, you probably will need to participate in behavioral therapies and group therapy programs, like the 12-step programs. Addiction is classified as a disease by the American Society of Addiction Medicine (ASAM) that is related to changes in brain structure and chemical makeup as the result of substance abuse. The main indicator of drug addiction is a loss of control over drug use. An individual battling addiction may make multiple attempts to stop using the drug, may take more than intended at one time, or may take the drug for longer than initially desired. Individuals suffering from addiction may use drugs in situations that could potentially be hazardous and continue abusing them even when negative consequences are clear. Prescription drugs are abused across almost all age, gender, race, cultural, and socioeconomic demographics, however.

Severe, long-term spasticity can lead to muscle contracture, which can decrease your range of motion or leave the affected joints permanently bent. And muscle spasms can not only be uncomfortable, they can also be a sign of an underlying medical problem. On March 21, 2022, Sandoz issued a voluntary recall of 13 lots of the drug orphenadrine citrate 100mg ER tablets due to the presence of nitrosamine. Nitrosamine, a known carcinogen with the potential to cause cancer, was found to exist in the drug at levels greater than the acceptable daily intake (ADI) as determined by the FDA. This recall is specific only to a handful of lot numbers and does not affect all orphenadrine tablets made by Sandoz. If you take orphenadrine citrate 100mg ER tablets, talk with your pharmacist or doctor and they will help you determine if your medication has been impacted by the recall.

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Skeletal muscle relaxants are widely used in treating musculoskeletal conditions. However, evidence of their effectiveness consists mainly of studies with poor methodologic design. In addition, these drugs have not been proven to be superior to acetaminophen or nonsteroidal anti-inflammatory drugs for low back pain. Systematic reviews and meta-analyses support using skeletal muscle relaxants for short-term relief of acute low back pain when nonsteroidal anti-inflammatory drugs or acetaminophen are not effective or tolerated. Comparison studies have not shown one skeletal muscle relaxant to be superior to another. Cyclobenzaprine is the most heavily studied and has been shown to be effective for various musculoskeletal conditions.

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This medicine may cause some people to have blurred vision or to become drowsy, dizzy, or less alert than they are normally. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert and able to see well. Make your tax-deductible gift and be a part of the cutting-edge research and care that’s changing medicine. You’ll soon start receiving the latest Mayo Clinic health information you requested in your inbox. This medicine is available only with your doctor’s prescription.

Missed Dose

If this medication upsets your stomach, take it with food or milk. Do not use the extended-release capsules if you have used an MAO inhibitor (MAOI) such as Eldepryl®, Marplan®, Nardil®, or Parnate® within 14 days of each other. If you cannot swallow the capsule whole, you may open the capsule and sprinkle the contents over one tablespoon of applesauce. Rinse the mouth to make sure all of the medicine have been swallowed. Do not take more of it and do not take it more often than your doctor ordered.

The sedative properties of tizanidine and cyclobenzaprine may benefit patients with insomnia caused by severe muscle spasms. Methocarbamol and metaxalone are less sedating, although effectiveness evidence is limited. Adverse effects, particularly dizziness and drowsiness, are consistently reported with all skeletal muscle relaxants. The potential adverse effects should be communicated clearly to the patient. Because of limited comparable effectiveness data, choice of agent should be based on side-effect profile, patient preference, abuse potential, and possible drug interactions.

  • A class of drugs is a group of medications that work in a similar way.
  • Adding plans allows you to compare formulary status to other drugs in the same class.
  • The capsule may be swallowed whole, but its contents also may be sprinkled onto a tablespoon of applesauce for immediate consumption without chewing the granules.
  • The National Institute on Drug Abuse (NIDA) notes that dependence can happen with chronic use of any drug, even when they are taken as prescribed.

This can help keep levels of this drug from building up too much in your body. It is also possible for serious cyclobenzaprine side effects to occur, like seizures, heart arrhythmias, heart attack, or stroke. These are more likely to occur when a person has too much cyclobenzaprine in their system, for instance, if their prescription dose is too high or if they are misusing the drug. Another telltale sign of Flexeril addiction is abusing the medication in combination with another substance to produce a greater sense of euphoria.

In the higher dose groups this microscopic change was seen after 26 weeks and even earlier in rats which died prior to 26 weeks; at lower doses, the change was not seen until after 26 weeks. The plasma concentration of cyclobenzaprine is increased in patients with hepatic impairment (see CLINICAL PHARMACOLOGY, Pharmacokinetics, Hepatic Impairment). Taking MAO inhibitors with this flexeril site:drugs.com medication may cause a serious (possibly fatal) drug interaction. Avoid taking MAO inhibitors (isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before treatment with this medication.

Safety and effectiveness of FLEXERIL in pediatric patients below 15 years of age have not been established. FLEXERIL may enhance the effects of alcohol, barbiturates, and other CNS depressants. Tell your doctor if you are pregnant or plan to become pregnant during treatment with Flexeril.

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